Hexaghen Product Details:

THE SCIENCE BEHIND HEXAGHEN.

HEXAGHEN FastSorb tablets belong to a new class of orally effective IGF-1 (Insulin-Like Growth Factor-1) stimulating compounds. HEXAGHEN utilizes a FastSorb delivery system for rapid absorption and maximum bioavailability.

THE SCIENCE OF INSULIN-LIKE GROWTH FACTOR-1 (IGF-1)

IGF-1 produced in the body possess some unique anabolic characteristics and is one of the most potent natural activators of the AKT signaling pathway, a stimulator of cell growth and multiplication. Attention was first turned to IGF-1 when scientists researching growth hormone discovered that Growth Hormone (GH) influence on IGF-1 production was the responsible factor for the anabolic effects associated with growth hormone administration and natural elevation in the body. In fact, while GH has direct fat burning effects as it metabolizes stored body fat, its muscle building effects are actually attributed to its effects on increasing IGF-1 levels. Therefore, it is IGF-1 and not GH that directly mediates muscle cell hyperplasia and muscle growth at the cellular level. IGF-1 is thought to be the critical mediator as it stimulates both the differentiation and proliferation of myoblasts (muscle cells), resulting in muscle growth. IGF-1 also enhances muscle growth by increasing amino acid uptake and protein synthesis.

IGF-1 is an important peptide hormone that is involved in regulating growth and development of muscle tissue. Its primary action is mediated by binding to specific IGF-1 receptors present on many cell types in many tissues. The free form IGF-1 fraction is highly bio-active in comparison to the IGF-1 bound to IGF Binding Proteins (IGFBPs). IGF-1 is the principal hormonal mediator of growth in the body. In the cascade of biochemical events leading to a surge in IGF-1 production and levels, HEXAGHEN stimulated growth hormone is metabolized by the liver and potentiates the synthesis and secretion of IGF-1.

Muscle tissue has an abundance of IGF-1 receptors. When serum IGF-1 binds to these receptor sites on muscle tissue, it stimulates the following anabolic actions and growth processes in humans, including increasing the number and size of muscle cells:

- Regulates cell growth and development
- Regulates cellular DNA synthesis
- Mediates muscle cell hyperplasia and muscle fiber development initiation and maturation.
- Stimulates the growth and size of muscle cells
- Stimulates glucose uptake by myoblasts (muscle precursor cells), which fuels their growth and development into muscle fiber cells
- Increases muscle cell uptake of amino acids, uses as building blocks of muscle protein molecules
- Increases nitrogen retention and a greater food conversion efficiency
- Reduces nitrogen excretion
- Improves wound healing
- Stimulates muscle protein synthesis
- Preferentially stimulates the growth of lean tissue
- Stimulates mitogenic (cell replication) activities that lead to an increased number of muscle cells in the body
- Vital for muscle repair and regeneration
- Causes improvements in body composition, demonstrating a decrease in body fat mass and a profound increase in lean body mass

The relationship within the endocrine/IGF-1 axis is a complex system. Scientists have recently identified other factors that play a critical role in effecting IGF-1 levels. Approximately 98% of IGF-1 is bound to one of several insulin-like growth factor binding proteins (IGFBP). IGFBP-3, the most abundant protein, accounts for 80% of all IGF-1 binding. Research has demonstrated that reducing IGF-1 binding proteins and maintaining higher levels of free IGF-1 is correlated to improved anabolic effects and muscle development.

As reported in independent research journals, thyroid function is also associated with enhancing IGF-1 bio-active tissue levels and further increasing the rate of protein synthesis. Therefore, as IGF-1 levels are increased, a series of negative feedback controls involving the thyroid endocrine axis are triggered to keep IGF-1 levels within a narrow physiological range; not too high and not too low.  From examining the relationships between GH, IGF-1 production, IGF-1 levels, free IGF-1, IGFBP, and thyroid function, MuscleMeds researchers addressed
this correlation between IGF-1 production and bio-effectiveness related to thyroid stimulation. HEXAGHEN’s synergistic thyroid
involvement is designed to help sustain higher total and free IGF-1 levels for longer periods of time, thereby extending the overall desired
IGF-1 anabolic effects.

Research and Development

The muscle building effects of IGF-1 have been well known and medically documented for years. But, the controlling factors regulating the body’s natural output have challenged researchers. Synthetic IGF-1 has been produced by major biotech pharmaceutical companies on a large scale using recombinant DNA technology. These synthetic forms must be administered via injection dosing. The development of an orally effective IGF-1 enhancing compound has long been a major global objective of biotechnologists.

After years of extensive research and laboratory analysis, MuscleMeds researchers discovered a unique IGF-1 stimulating hexapeptide
(GHRP-2 Hexapeptide Acetate).  Due to its long hexapeptide structure, the development of an effective oral dosage form for GHRP-2 Hexapeptide posed some biotechnical challenges. Conventional oral dosing (such as tablets, capsules, liquids and softgels) was ineffective due to the gastrointestinal destruction of the GHRP-2 hexapeptide. As with other peptide substances, GHRP-2 hexapetide is subject to destruction (breakdown) in the gastrointestinal system, which eliminates the effectiveness and ability to reach the hypothalamus-pituitary axis. In order to create a product that is suitable for oral administration of the HEXAGHEN GHRP-2 Hexapeptide acetate, MuscleMeds scientists employed the utilization of their proprietary FastSorb delivery system technology.

As a result of this researched based product development effort, HEXAGHEN features a unique IGF-1 Optimizing Complex. HEXAGHEN’s novel ingredient composition and proprietary liposomal delivery system is designed to stabilize the bioactives for rapid and high levels of absorption directly into the blood stream primarily through buccal cavity (mouth) absorption. Oral mucosal dosage delivery (transmucosally) is an alternative method of systemic nutrient delivery, which offers several advantages as the oral mucosa is highly vascularised with absorptive abilities. Therefore, HEXAGHEN’s active compounds are absorbed through the oral mucosa directly enter the bloodstream, bypassing the gastrointestinal tract and first-pass metabolism in the liver. This improves the bioeffectiveness of delivery into the body, to trigger a series of endocrine medicated events: HEXAGHEN stimulates GH and IGF-1 levels and supports thyroid function for maximum effects.

Hexaghen Supplement Facts:
Serving Size: 2 tablets
Servings Per Container: 28
        
Amount Per Serving:
HEXAGHEN [Patent Pending IGF-1 Complex of: Ketonic Isomers(cis and trans-4,17(20)-pregnadiene-3,16-dione), GHRP-2 Hexapeptide Acetate] 12.6 mg
 
Hexaghen Other Ingredients:
lactose, mannitol, methylcarboxy cellulose, calcium carboxycellulose, phosphatidyl choline, phosphatidyl serine, palmitic acid, EDTA natural and artificial citrus flavors, FD&C Red 40.

Hexaghen Recommended Use:
Hexaghen FastSorb tablets are designed to be dissolved under your tongue. Hexaghen should be taken 30 minutes before bedtime. Place 2 Hexaghen FastSorb tablets under your tongue and let dissolve completely, then swallow. DO NOT EXCEED 2 TABLETS PER DAY. 6 Week Cycling Instructions 2 weeks on (14 days) 1 week off (7 days), 2 weeks on (14 days) 1 week off (7 days) (Then Repeat Cycle)

Warning:
NOT FOR USE BY INDIVIDUALS UNDER THE AGE OF 18 YEARS. DO NOT USE IF PREGNANT OR NURSING. Consult a physician or licensed qualified health care professional before using this product. Do not exceed the recommended serving. Discontinue use and call a physician or licensed qualified health care professional immediately if you experience any adverse effects. To report any adverse event call 1-800-332-1088.
KEEP OUT OF REACH OF CHILDREN.