11 OXO Product Details:
Announcing a hormone control breakthrough from Ergopharm. Ergopharm
proudly introduces 11-OXO™, the first selective inhibitor of
11b-hydroxysteroid dehydrogenase type I reductase. Finally . . .
cortisol control that delivers on the promises.
Ergopharm has found the key to obtaining:
- Decreased body fat (especially visceral adipose tissue)
- Increased muscle density (hardness)
- Enhanced insulin sensitivity and glycogen deposition
- Increased strength
- Improved brain and CNS function
Introducing Ergopharm's boldest new product release in years.
11-OXO is a highly effective body recompositioning agent that takes
advantage of some of the most cutting edge medical research on hormone
metabolism and health. This is breakthrough technology here, but more
importantly beyond all the scientific explanations of its mechanisms we
truly have a product that works phenomenally well!! Equally important,
we have a natural physique transformer that not only has an impressive
safety profile but also actually promotes overall health in a plethora
of ways.
What is 11-OXO?
11-OXO is the trademark name for adrenosterone. Adrenosterone is an
adrenal androgen. “Adrenal androgen” means it is a hormone produced by
the adrenal gland that is in the same general hormonal class as
testosterone (another example of an adrenal androgen is DHEA).
Adrenosterone is released by the adrenal gland in conjunction with
other stress hormones, primarily cortisol and cortisone. The exact
function of adrenosterone has never been fully understood, however
recent research seems to indicate that it serves to modulate the
actions of cortisol in the body.
Cortisol is a vital hormone made by the adrenal gland and it is
considered a stress hormone. When your body is stressed it seeks to
quickly liberate energy stores and cortisol assists this by stimulating
the breakdown of muscle protein to amino acids and stored triglycerides
(fat) to free fatty acids. It also instructs the liver to up-regulate
its systems for processing these fuels - the gluconeogenesis pathway
for amino acids and the beta-oxidation pathway for fats.
The catabolic consequences of elevated cortisol on muscle tissue is
pretty clear-cut and well understood by most bodybuilders. The effects
of cortisol on body fat content and distribution, and on vital
metabolic pathways in the liver however are not. Even less understood
are the tissue specific controls that activate and deactivate cortisol
on a local level throughout the body. I am talking about enzymes
located at places like the liver, visceral fat, brain, vascular tissue,
and (yes) skeletal muscle that serve to control whether cortisol is
activated or deactivated within these tissues themselves. It is these
enzyme systems that scientists are now recognizing as perhaps the most
significant metabolic aspect of cortisol in regards to body
composition, heart disease, diabetes, and other maladies that together
have come to be known as "Syndrome X". And most importantly, it is this
localized enzyme system that holds spectacular medical promise as a
pharmacological target to greatly improve health and physical fitness
Fat and cortisol
I mentioned how cortisol release liberates fat for use as energy.
Upon hearing me say that you probably thought to yourself that cortisol
must have an overall effect in the body of reducing body fat. That is
not the case however. Cortisol affects fat metabolism and storage in
the body in a multitude of ways. To best achieve an overall
understanding of cortisol’s effect on body fat we should keep mind of
cortisol's overall purpose in the body, which is to help your body
respond to stress. Cortisol controls both immediate and long-term
adaptations to stress within the body. Of course the immediate effects
on body fat are the release of energy in the form of fatty acids, but
cortisol also goes to work on setting the stage within your body so
that it will have an ample resource of the most easily accessible body
fat stores to draw upon in the future.
What I mean by the most easily accessible body fat in the body is
the kind of body fat that cortisol can most readily tap into when
urgent fatty acid energy is needed. I am talking here primarily about
visceral fat. Visceral fat has a direct root to the liver via the
portal system so it is perfectly positioned to provide a quick supply
of fatty acid fuel for immediate processing. Simply put, this is the
fat located around your internal organs. It is the fat that gives you
the potbelly look and it is also the fat that is most closely
associated with health risks such as heart disease, diabetes, and
perhaps even cancer. For me personally, as it is for many adult males,
visceral fat is a constant source of disgust against which I fight a
constant battle.
What cortisol does in the body over time is switch the distribution
of fat away from the more stubborn areas (such as the subcutaneous fat
in the extremities) to the more highly cortisol sensitive areas of the
body. These areas include the viscera as I mentioned already but also
include oddball areas such as the upper back and face. The classical
phenotype (physical appearance) of the individual suffering from
cortisol excess is the "pot belly", "buffalo hump", and "moon face".
Not a pretty sight I know.
Cortisol and the liver
Ok now what about the effects of cortisol upon liver. If you are a
hopeless muscle head you may be asking "why should I give a damn about
my liver"? Well I will explain to you why, and you will see that for
several reasons the negative effects of cortisol on the liver can have
a profound impact upon your ability to build muscle. The liver is the
number one target of cortisol in the body and it is also the number one
area where it is metabolized. Cortisol has a ton of actions in the
liver but to make this short and sweet I will stick to the ones that
are most relevant to bodybuilders.
First of all, cortisol affects carbohydrate metabolism. It lowers
insulin sensitivity and switches on the pathways of gluconeogenesis.
Gluconeogenesis is the formation of glucose from non-carbohydrate
precursors, primarily amino acids. What this means is that it turns
your liver into an amino acid devouring machine, turning amino acids
that your muscles need to grow into sugar - sugar that will probably
mostly end up later being made into fat. Cortisol also negatively
influences the levels of IGF-1 in the body by a few mechanisms, most
notably by decreasing the IGF-1 production response to growth hormone
and increasing the production of the deactivating factor IGF-1 binding
protein-1. Furthermore, cortisol down regulates the T3-deiodinase
enzyme in the liver resulting in a lowering of thyroid hormone
activity. Look, I can go on and on about cortisol's terrible influence
on the liver but I am getting as bored with the liver as you probably
are right now so I want to move on. I think you get the point
Goes on and on
Before I go on to the important part of the story here let me just
wrap up the background with some mention of other tissues of relevance
to the physique enthusiast. Vascular tissue suffers from excess
cortisol by becoming more sensitive to hormones, which influence
constriction (i.e. adrenaline, angiotensin II). Furthermore, cortisol
inhibits vasodilation by decreasing the biosynthesis of nitric oxide
and prostaglandin 1 as well as attenuating the actions of atrial
naturietic peptide. This can result in elevated blood pressure
(hypertension) and a decreased vasodilatory response to exercise (in
english that translates to a decrease in the ability to get a good
pump). As for the brain, it is not immune from cortisol's ravages
either. Cortisol reduces the release of LH, GH, and TSH from the
pituitary resulting in reductions in circulating levels of the anabolic
hormones testosterone, IGF-1, and triidothyronine (T3). The
testosterone producing leydig cells of the testicles also are directly
adversely affected by cortisol so along with the LH suppression you get
a double whammy against testosterone. Last but not least are the
muscles themselves which I don't have to elaborate on. You already know
that cortisol breaks down muscle protein into amino acids that then get
converted to glucose for energy and fat production.
11HSD1R is the target
So now onto the main point. All of these parts of the body that are
influenced by cortisol action contain the enzymes I mentioned earlier
that control the local concentration of this dastardly hormone. Which
means all these tissues are targets for enzyme blockers that will
protect them from all of this. And that is what this is all about. It
is not just theory either; the practical solutions are actually
presently attainable. Now lets talk about the enzymes themselves
without getting too bogged down in laborious technicalities (I hope).
Cortisol belongs to a group of hormones collectively known as
glucocorticoids. Glucocorticoids are steroid hormones just like
testosterone, progesterone, and estrogens are. The hallmark of an
active glucocorticoid molecule is a part of the steroid structure known
as the 11beta hydroxyl group. This chemical group is essential for the
activity of cortisol or any other glucocorticoid. In the body, this
11beta hydroxyl group is constantly being converted into what is known
as an 11-oxo group and then back again into the 11beta hydroxyl. This
is what is known as an equilibrium reaction. Anyway, 11-oxo's are
inactive glucocorticoids and the 11-oxo version of cortisol is known as
cortisone.
So to summarize so far, cortisol is active and cortisone is
inactive. Cortisol is an 11beta-hydroxyl and cortisone is an 11-oxo.
In the blood, there is more cortisone than cortisol. So if these
target tissues (fat, liver, muscle etc) want a decent shot of cortisol
they have to convert some of that cortisone into cortisol themselves.
And they do this with an enzyme known as 11beta-hydroxysteroid
dehydrogenase type1 reductase (11HSD1R for short). In recent years a
tremendous amount of research has been directed towards this enzyme and
its vital role in the body. It has been recognized as a metabolic
regulatory mechanism of huge significance for some of our societies
most widespread and insidious health threats - cardiovascular disease,
diabetes, and obesity just to name a few.
The great thing about the discovery of this enzyme and the fact
that its activity can be influenced is that it offers us a method of
controlling the negative actions of cortisol on the body without
blocking cortisol's vital functions necessary for life. It is important
to remember that although excess cortisol is undesirable, maintaining a
crucial minimal supply of this hormone is essential to our health.
Eliminating it or reducing it inappropriately can result in severe
health consequences. In fact, this is what has been the problem with
cortisol suppression approaches of the past. Non-specific approaches
that reduce cortisol production (aminoglutethimide, trilostane) or
cortisol receptor binding (mifepristone) basically throw the baby out
with the bath water. They eliminate the problems of cortisol excess all
right but in exchange they present the patient with a new set of
problems - problems associated with cortisol deficiency such as
weakness, loss of weight, low blood pressure, and gastrointestinal
disturbances.
So what are the ways of blocking this enzyme? First of all you must
be aware that there are other cortisol metabolism enzymes closely
related to 11HSD1R such as 11-beta hydroxysteroid type1 dehydrogenase
and 11beta-hydroxysteroid dehydrogenase typeII. You do NOT want to
block these enzymes - the former will increase cortisol levels in
target tissues while the latter will cause your kidneys to go nuts and
raise your blood pressure through the roof. So you need a selective
inhibitor. This is not easy. There are lots of non-selective inhibitors
around but few selective ones.
Interestingly enough, some hormones our body make naturally are quite
good selective inhibitors of 11HSD1R. Most notable are GH and IGF-1,
and it is no surprise that the body recomposition powers of these
hormones are not in small part due to their effect on 11HSD1R. But
there are other endogenous hormone inhibitors of this enzyme, many of
which are made by the same gland which makes cortisol itself and which
possess many of the same key chemical structural characteristics while
lacking cortisol's activity. It is these hormones that I find most
fascinating and which have the potential for use by the average
bodybuilder (without a prescription.) You see, in addition to cortisol,
cortisone, and other similar glucocorticoids, the adrenal gland
produces a strange series of steroid hormones that also possess
11beta-hydroxyl and 11-oxo chemical functional groups. These include
progesterone type hormones like 11-oxoprogesterone and androstene type
hormones such as adrenosterone. Adrenosterone in my opinion holds the
most promise for athletes a safe, effective, and selective cortisol
modulating performance enhancing and body recompositioning agent and is
the compound found in 11-OXO
How 11-OXO works to inhibit 11HSD1R is actually pretty
straightforward. 11-OXO simply occupies the enzyme, preventing
cortisone from accessing it. This is known as competitive inhibition.
If cortisone cannot access 11HSD1R then it won't have the opportunity
to be converted to cortisol at the target tissue. The 11HSD1R enzyme
acts the same way on 11-OXO as it does on cortisone, that is it reduces
the 11-oxo functional group to an 11beta-hydroxyl functional group -
only in this case it is converting 11-OXO into another hormone known as
11beta-hydroxyandrostenedione.
Controlling cortisol via 11HSD1R is still a new frontier but it is
an area of health and physique enhancement that I feel has enormous
potential and just might prove to be a godsend for a lot of health
conscious individuals. For bodybuilders in particular I feel that in
conjunction with other biochemical manipulations (supplements,
steroids, etc.) this approach may provide an amplification of effects
that are pronounced and impressive. But in my opinion all that pales in
comparison to what we may see in regards to overall health, vitality,
and life extension benefits. We have a real possible win-win situation
here, as what we are talking about is a way to build muscle and lose
fat, while extending life and overall health at the same time.
Totally natural hormone
Adrenosterone is found in the blood of both men and women. For men it
is present in the blood at a concentration about 1/10 that of
testosterone, and in women it is actually present in amounts roughly
33% greater than men.
In most species including humans it is produced in the adrenal gland
under the influence of adrenocorticotropic hormone (ACTH). However in
many fish, including salmon, tilapia, eel, trout, bass, and others it
is produced in the testes along with 11-oxotestosterone (which is
actually the major androgen in many fish)
*It is important to mention that being a precursor to the active
androgen 11-oxotestosterone, exceeding the recommend dose and duration
of use may result in increased risk of androgenic side effects and HPTA
suppression. This suppression while minimal at the recommended dosage,
can temporarily effect fertility and sex hormone production at higher
dosages. This directed use of this product is specifically designed to
selectively provide cortisol modulation while minimizing sex hormone
activity. Please do not exceed recommended dosage. This product is to
be used by males only.
11 OXO Supplement facts:
Servings Per Container: 20
Serving Size: 3 capsules
Amount Per Serving:
11-OXO (adrenosterone) 225mg
11 OXO Other Ingridents:
Gelatin, microcrystalline celluose, modified cornstarch, magnesium stearate, silica.
11 OXO Recommended Use:
Take 3 to 6 capsules per day with food for no more than 8 weeks at a time.
Examples of 11 OXO cycles are listed below. 6-OXO Extreme can be substititued for 6-OXO in any of these stacks.
Low Dose:
Day 1-40: 11 OXO 1 capsule 3 times per day with meals
Day 41-60: 6-OXO 3 capsules 2 times per day with breakfast and dinner
Higher Dose:
Day 1-40: 11 OXO 2 capsules 3 times per day with meals
Day 41-60: 6-OXO 3 capsules 2 times per day with breakfast and dinner
An interesting alternative to this method is the stagger method. A staggered cycle can take the form of the following:
Stagger Dose:
Day 1-4: 11 OXO 2 capsules 3 times per day with meals
Day 5-8: 6-OXO 3 capsules 2 times per day with breakfast and dinner
Day 9-12: 11 OXO 2 capsules 3 times per day with meals
Day 13-16: 6-OXO 3 capsules 2 times per day with breakfast and dinner
Day 17-20: 11 OXO 2 capsules 3 times per day with meals
Day 21-24: 6-OXO 3 capsules 2 times per day with breakfast and dinner
Day 25-28: 11 OXO 2 capsules 3 times per day with meals
Day 29-32: 6-OXO 3 capsules 2 times per day with breakfast and dinner
Day 33-36: 11 OXO 2 capsules 3 times per day with meals
Day 37-40: 6-OXO 3 capsules 2 times per day with breakfast and dinner
Warning:
Consult with your phsycian before using this product.Not recommended
for use by women. Not recommended for persons under the age of 18. Keep
out of the reach of children. Before beginning any program of weight
loss, consult your health care practitioner. These statements have not
been evaluated by the FDA. This product is not intended to diagnose,
treat, cure or prevent any disease.
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